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Chronic fatigue syndrome

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Fast facts

What is chronic fatigue syndrome?

Chronic fatigue syndrome is an illness characterized by debilitating fatigue. The key feature of chronic fatigue syndrome is a worsening of symptoms after physical, emotional and mental activity, and the need for a long period of recovery. Activities that used to be enjoyable and straightforward start to take a toll on the person's health, causing fatigue that can last for days. There is much variation between people in the level and frequency of activity that they can carry out before symptoms worsen.

The fatigue associated with this condition is not normal fatigue and is not simply cured with rest.

Chronic fatigue syndrome can affect men, women and children of any age and is estimated to affect an estimated 836,000 to 2.5 million Americans.

Causes

The cause of chronic fatigue syndrome is yet to be fully understood. Factors that may be causing or contributing towards the syndrome include:

Risk factors

Chronic fatigue syndrome is:

  • More frequently diagnosed in women;
  • More frequently diagnosed in young to middle-aged adults, and;
  • Frequently diagnosed alongside fibromyalgia and multiple chemical sensitivities.

Signs and symptoms

Chronic fatigue syndrome does not necessarily follow a predictable course. Symptoms can change in their severity and frequency between people. Symptoms can also vary for one person at different times.

The main symptom is overwhelming weariness that usually follows exertion. The person quickly becomes very tired physically, and can find it difficult to focus or think clearly.

Other symptoms can vary widely between people, but some of the more typical symptoms may include:

People with a mild form of chronic fatigue syndrome can generally continue their regular lives, but they may need to switch to part-time work or study, reduce their recreational activities, and may need occasional assistance.

The moderate form of chronic fatigue syndrome usually makes it too difficult for a person to continue work or study. They may need considerable help with routine tasks. Quality of sleep can also suffer.

The severe forms of chronic fatigue syndrome typically leave people unable to work or study. Some people may need to use a wheelchair for mobility and may find it very hard to leave the house. They are highly dependent on others.

Severe forms of chronic fatigue affect work performance and the carrying out of routine tasks. 

Methods for diagnosis

There is no single test used to diagnose chronic fatigue syndrome. The diagnosis is made by ruling out other conditions that can cause fatigue, such as:

For a diagnosis of chronic fatigue syndrome, the symptoms need to have been severe enough to significantly impair a person's normal activity level for at least six months (three months in children). The fatigue needs to be:

Four or more of the following symptoms also need to persist or recur during six or more consecutive months:

Laboratory tests

Your doctor may also perform blood tests to evaluate your overall health and to look for any underlying conditions or problems, such as inflammation or thyroid disorders.

Types of treatment

There is no universally successful treatment for chronic fatigue syndrome. Treatment focuses on managing symptoms to improve the quality of life. The treatment depends on the individual and their specific symptoms.

There is currently no clear evidence that medication or dietary supplements help treat chronic fatigue syndrome.

Graded exercise therapy

This involves working with a trained healthcare professional to establish your baseline activity level, and a program to gradually increase the amount of time you can tolerate physical and mental activities. A target heart rate range is set, to avoid over-exertion.

Although exercise may temporarily worsen symptoms, completely ceasing all exercise can make symptoms worse. There is considerable evidence that graded therapy can help improve tiredness and physical functioning.

Cognitive behavior therapy

This 'talking therapy' typically involves a series of sessions designed to identify beliefs and behaviors that may be delaying recovery, to alter negative thinking patterns, and to develop alternative ways of thinking and acting.

This therapy has been shown to offer long-term improvement in fatigue and physical function and can help improve school attendance for teenagers with the condition.

Complementary therapy

Acupuncture, massage and yoga may help people to relax, increase their energy, and treat muscular aches and pains.

Potential complications

Complications of this syndrome include depression, social isolation, lifestyle restrictions and increased absences from study or work.

Prognosis

Although there is no known cure for chronic fatigue syndrome, the relief of symptoms is possible, to some extent. The length of the illness is difficult to predict and can vary between people. For some, symptoms may last for months or years, while others may have relapses and periods of remission over a matter of years.

Prevention

There is no known prevention for chronic fatigue syndrome.

References

  1. Myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS). ME/CFS Australia (SA) Inc. Accessed 24 April 2015 from link here
  2. About ME/CFS | ME/CFS Australia (Victoria). Accessed October 6 2014. link here
  3. Aspler Anne L Carly Bolshin Suzanne D Vernon and Gordon Broderick. “Evidence of Inflammatory Immune Signaling in Chronic Fatigue Syndrome: A Pilot Study of Gene Expression in Peripheral Blood.” Behavioral and Brain Functions 4 no. 1 (2008): 44. doi:10.1186/1744-9081-4-44.
  4. Australia) Child and Youth Health-CYH (South. “Chronic Fatigue Syndrome.” Accessed October 6 2014. link here
  5. CDC - Improving Health and Quality of Life - Chronic Fatigue Syndrome (CFS). Accessed October 6 2014. link here
  6. Choices N. H. S. “Chronic Fatigue Syndrome - NHS Choices” June 23 2014. link here
  7. Chronic Fatigue Syndrome.Accessed October 6 2014. link here
  8. Chronic Fatigue Syndrome (CFS). Better Health Channel. Accessed October 5 2014. link here
  9. myDr. “Chronic Fatigue Syndrome - myDr.com.au.” Resource. Accessed October 6 2014. link here
  10. RACGP - Chronic Fatigue Syndrome – a Patient Centred Approach to Management.Accessed October 6 2014. link here
  11. Explainer: What Is Chronic Fatigue Syndrome? The Conversation. Accessed October 6 2014. link here
  12. Snapshot.” Accessed October 6 2014. link here
  13. Vermeulen Ruud CW Ruud M Kurk Frans C Visser Wim Sluiter and Hans R Scholte. “Patients with Chronic Fatigue Syndrome Performed Worse than Controls in a Controlled Repeated Exercise Study despite a Normal Oxidative Phosphorylation Capacity.” Journal of Translational Medicine 8 no. 1 (2010): 93. doi:10.1186/1479-5876-8-93.

10 Most frequently asked questions (FAQs)

What is chronic fatigue syndrome?
Chronic fatigue syndrome is a complex condition that causes debilitating fatigue and a range of other symptoms that can affect multiple systems of the body.
What are the symptoms of chronic fatigue syndrome?
The symptoms of chronic fatigue syndrome can vary between people, but some of the more common symptoms may include: being easily fatigued; headache; difficulty with memory and concentration; sore throat; muscle and joint aches; difficulty sleeping, and; experiencing anxiety or depression.
What causes chronic fatigue syndrome?
The cause of chronic fatigue syndrome is yet to be fully understood.
Who gets chronic fatigue syndrome?
Although anybody can potentially develop it, chronic fatigue syndrome is more common in women and young to middle-aged adults.
How is chronic fatigue syndrome diagnosed?
The diagnosis of chronic fatigue syndrome is based on ruling out other conditions, and on the presence of a persistent fatigue of at least 6 months that is accompanied by four or more of the following: non-refreshing sleep; sore throat; impaired short-term memory or concentration; muscle pain; headache, and; post-exertion malaise (feeling unwell after physical exercise or strain) that lasts more than 24 hours.
How is chronic fatigue syndrome treated?
Although there have been many advances in giving medication for chronic fatigue syndrome, there is not yet any one known cure for the condition. Effective treatment is presently based on behavior therapy and graded exercise therapy.
Can chronic fatigue syndrome be cured?
There is at present to effective cure for chronic fatigue syndrome.
Will chronic fatigue syndrome clear on its own?
The course of chronic fatigue syndrome can be highly unpredictable. Following a treatment plan has been shown to effectively improve outcomes, whereas failing to seek appropriate healthcare may impede the recovery.
Can chronic fatigue syndrome be prevented?
There is no known prevention for chronic fatigue syndrome.
How common is chronic fatigue syndrome?
Chronic fatigue syndrome is estimated to affect about 150,000 Australians.

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About this article

Title: Chronic fatigue syndrome

Author: Dr Nikki Wallis PhD, BSc

First Published: 04 Dec 2014

Last reviewed: 17 Jan 2022

Category: Information on Chronic fatigue syndrome

Average rating: 4.2 out of 5 (1556 votes)

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