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Ischaemic stroke

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What is ischaemic stroke?

There are two main types of stroke: ischaemic stroke and hemorrhagic stroke. Ischaemic strokes account for about 80% of all stroke cases. An ischaemic stroke occurs when an artery supplying oxygen-rich blood into the brain is blocked and oxygen cannot reach the brain tissue.

This page details the types of ischaemic stroke and the treatment given. For more information on stroke signs and symptoms, diagnosis, complications and rehabilitation, see our stroke report.

Types

There are two main types of ischaemic stroke: thrombotic stroke and embolic stroke. A transient ischaemic attack (TIA) is not a stroke proper, but a temporary neurological episode.

Thrombotic stroke

A thrombotic stroke is caused by a blood clot that forms within an artery in the brain. It arises from fatty deposits (plaques) that build up inside the artery, a condition known as atherosclerosis. These plaques can rupture, which creates a surface for a blood clot to form. This clot can completely block the artery.

Large arteries of the brain, which are the main blood supply to the brain, are more likely to be blocked by thrombotic strokes than embolic strokes. This is why a thrombotic stroke is most likely to have larger-scale effects.

Thrombotic strokes account for more than half of all strokes.

Embolic stroke

An embolic stroke is caused by a blood clot that travels from elsewhere in the body and lodges in an artery in the brain. The blood clot (embolus) that causes the stroke is commonly the result of existing heart problems, such as atrial fibrillation or aortic stenosis (the abnormal narrowing of the aortic valve).

Types of Ischaemic stroke. 

Transient ischaemic attack

A transient ischaemic attack (TIA), also known as a 'mini-stroke', is caused by a temporary blockage or narrowing in a blood vessel leading to the brain. A person experiencing TIA will have signs and symptoms like those of a stroke, but will recover within minutes or a few hours.

It is important to note that a TIA is a warning sign. TIAs occur when the blood vessels feeding the brain are not in good condition; a person who has had a TIA is at risk of stroke, often within days of the TIA.

For more information on TIAs, see our transient ischaemic attack report.

Types of treatment

Stroke is a medical emergency, and should be treated at a hospital. The immediate concern during an ischaemic stroke is to restore normal blood flow to the brain by dissolving the blood clot.

Medication

Once an ischaemic stroke is diagnosed, medicines are injected into the bloodstream that will dissolve the blood clot, prevent it from growing bigger and prevent other clots forming. These include:

Meanwhile, treatment of ischaemic stroke must also focus on stabilizing the patient's condition - mainly taking care of their blood pressure and their breathing status.

Surgery

In some cases, a blood clot can also be removed surgically - by carotid endarterectomy or cerebral angioplasty.

Carotid endarterectomy.

Carotid arteries are the two main arteries in the neck that supply the brain with blood. If they are clogged, carotid endarterectomy can be tried. An incision is made in the neck and the internal lining of the artery that contains the plaque is removed.

Cerebral angioplasty

Cerebral angioplasty is also known as stenting. Angiography is used to direct a thin catheter to the blood clot, where a collapsible wire basket is used to then extract the blood clot. A balloon is then used to dilate the blood vessel, before a small cylinder, called a stent, is left in the blood vessel to keep blood flowing to the brain.

Rehabilitation

After the cause of stroke has been successfully treated, the rehabilitation stage can begin. Its general goals are to restore the person to normal function if possible and to prevent complications. The character, length, intensity and outcome of this stage are different for every person.

For more information on stroke rehabilitation, see our stroke page.

References

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  3. Broderick J.P. Palesch Y.Y. Demchuk A.M. et al. (2013). Endovascular Therapy after Intravenous t-PA versus t-PA Alone for Stroke. New England Journal of Medicine 368: 893–903.
  4. Ciccone A. Valvassori L. Nichelatti M. et al. (2013). Endovascular Treatment for Acute Ischemic Stroke. New England Journal of Medicine 368: 904–913.
  5. Ding D. (2014). Intravenous Versus Intra-arterial Thrombolysis for Acute Ischemic Stroke Secondary to Basilar Artery Occlusion. Journal of Cerebrovascular and Endovascular Neurosurgery 16: 39–41.
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  8. Grip O. Kuoppala M. Acosta S. et al. (2014). Outcome and complications after intra-arterial thrombolysis for lower limb ischaemia with or without continuous heparin infusion. British Journal of Surgery 101: 1105–1112.
  9. Hackett M.L. Köhler S. O’Brien J.T. et al. (2014). Neuropsychiatric outcomes of stroke. The Lancet Neurology 13: 525–534.
  10. Hemorrhagic stroke treatment. Accessed 5 August 2014 from link here
  11. Ischemic stroke treatment. Accessed 5 August 2014 from link here
  12. Kidwell C.S. Jahan R. Gornbein J. et al. (2013). A Trial of Imaging Selection and Endovascular Treatment for Ischemic Stroke. New England Journal of Medicine 368: 914–923.
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  17. Stroke. Better Health Channel. Accessed 5 August 2014 from link here
  18. Stroke Information | cdc.gov. Accessed 5 August 2014 from link here
  19. Stroke Information Page: National Institute of Neurological Disorders and Stroke (NINDS). Accessed 5 August 2014 from link here
  20. Stroke symptoms and diagnosis. Accessed 5 August 2014 from link here
  21. Transient ischemic attack. Accessed 5 August 2014 from link here
  22. Van der Worp H.B. & van Gijn J. (2007). Acute Ischemic Stroke. New England Journal of Medicine 357: 572–579.
  23. What Is a Stroke? - NHLBI NIH. Accessed 5 August 2014 from link here
  24. WHO | Stroke Cerebrovascular accident. WHO. Accessed 5 August 2014 from link here

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About this article

Title: Ischaemic stroke

Author: Dr Idan Ben-Barak PhD, MSc, BSc (Med)

First Published: 16 Jul 2015

Last reviewed: 17 Jan 2022

Category: Information on Ischaemic stroke

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