The feeling of low libido can affect both men and women who are sexually active. Low libido may be a result of factors such as anxiety about previous performance; psychological issues including stress, depression or low self-esteem; familiarity with a sexual partner; physical turn-offs caused by changes in appearance; pain during sex; tiredness or fatigue; previous traumatic experiences (such as rape or sexual abuse); hormone changes during menopause or pregnancy; medication (such as antidepressant medication), alcohol or drugs; Illnesses (such as diabetes, thyroid disorders, heart disease or cancer), and; a deficiency in male hormones (such as testosterone).