Throat cancer occurs when abnormal cells grow uncontrollably in the throat. Cancer can develop in any of the three different parts of the throat:
Anatomy of the throat.
The cause of throat cancer, as with other cancers, is due to damage to cellular DNA. This results in uncontrolled growth of damaged cells, which leads to the formation of a cancer. The cancer can invade nearby tissues, or spread via the bloodstream or lymphatic system to other areas of the body.
The exact cause of throat cancers is not well known. However, certain risk factors are known to increase the risk of developing this condition.
A network of vessels, lymph nodes, the spleen and other organs that transport lymph fluid between tissues and bloodstream.
Risk factors for throat cancer include:
Smokers are three to four times more likely to develop a nasopharyngeal cancer than non-smokers. The risk of developing this cancer depends on how much you smoke and how long you have smoked for. Even if you only smoke pipes or cigars, or chew tobacco, you still have an increased risk of developing throat cancers.
Regular alcohol consumption greatly increases the risk of developing throat cancer, but smoking at the same time increases this risk several-fold.
An infection with human papilloma virus (HPV), Epstein-Barr virus (EBV) or herpes simplex virus (HSV) increases your risk of developing throat cancers. HPV and HSV are sexually transmitted viruses, therefore the risk of infection with these viruses can be reduced by practicing safe oral sex.
If you have HIV/AIDS, you have double the risk of developing nasopharyngeal cancer.
A diet low in fruit and vegetables increases your risk. Folate has been found to have a protective effect against throat cancer.
A virus of the herpes family that causes mononucleosis, also known as mono or glandular fever. It is also implicated in some other medical conditions.
A virus transmitted mainly by sexual or blood-to-blood contact, that infects cells of the immune system. It is the causative agent of acquired immune deficiency syndrome (AIDS).
The type of cancer can be classified by the type of cells, the cancer develops in:
Squamous cell carcinoma originates in the squamous cells, which are flat cells that line the inside of the mouth, nose and throat. The vast majority of nasopharyngeal and oropharyngeal cancers are squamous cell carcinomas.
Adenocarcinoma is a rare type of cancer that develops in the glandular cells of the throat.
Sarcomas are cancers of the body's connective tissue and are extremely rare in the throat. The connective tissue of the larynx is cartilage. The name for a cancer that originates in the cartilage is chondrosarcoma.
Lymphomas are cancers of the lymph nodes. There are many lymph nodes in the neck and lymphomas can cause painless swelling of these lymph nodes.
A tough, flexible connective tissue found in various parts of the body including the joints and larynx.
Specialized cells that secrete materials such as lubricants and hormones.
Treatment outcomes can vary greatly, depending on the stage of the cancer. Cancer is staged according to the size and location of the primary cancer and whether it has spread to lymph nodes or organs in the body.
| Stage 0 | This stage is also known as carcinoma in situ. It is when abnormal cells are found, but they have not yet become cancerous or spread beyond the place they first appeared. |
| Stage I | The cancer is in the nasopharynx only, or has spread to the middle part of the back of the throat (oropharynx) and/or nasal cavity. |
| Stage II | The cancer is in the nasopharynx only, or has spread to the middle part of the back of the throat (oropharynx) and/or the nasal cavity and to local lymph nodes. Also includes a tumor that has spread to the connective tissue that fills the space in the jaw bone at the base of the skull and includes one or more local lymph nodes. |
| Stage III | Stage III cancer is found in the same areas as Stage II cancer but has spread to lymph nodes on both sides of the neck or the cancer has spread to nearby sinuses and bone. |
| Stage IVA | The cancer is within the skull and may affect its nerves, the eyes, nearby tissue or the throat. The cancer might have spread to lymph nodes on both sides of the neck, but they are above the collarbone and not greater than six centimeters (2.36 inches). |
| Stage IVB | The tumor might have grown into nearby tissue or bone. It has also spread to at least one lymph node greater than six centimeters (2.36 inches), or to the collarbone, or both. |
| Stage IVC | The cancer has spread to distant sites in the body. |
| Stage 0 | This stage is also known as carcinoma in situ. It is when abnormal cells are found, but they have not yet become cancerous or spread beyond the place they originated. |
| Stage I | The tumor is less than two centimeters (0.79 inches) in diameter and has spread deep into the lining of the tissue in the mouth or oropharynx, but not to nearby organs or lymph nodes. |
| Stage II | The tumor is two to four centimeters (0.79 to 1.57 inches) in diameter and has not spread to lymph nodes or organs. |
| Stage III | The tumor is greater than four centimeters (1.57 inches) in diameter, but has not spread to lymph nodes or organs; or the tumor is any size and has spread to a single lymph node on the same side of the neck the tumor is located. |
| Stage IVA | The tumor has grown through the tissue around the lip and mouth and may have spread to lymph nodes in the area. |
| Stage IVB | The tumor is any size and the cancer has spread to multiple lymph nodes on the same side of the neck as the tumor; or to both sides of the neck; or to any lymph node greater than six centimeters (2.36 inches) in size. |
| Stage IVC | The cancer has spread throughout the body to distant organs. |
| Stage 0 | This stage is known as carcinoma in situ. It is when abnormal cells are found, but they have not yet become cancerous or spread beyond the place they originated. |
| Stage I | The tumor is only in one section of the throat and doesn't affect the vocal cords. |
| Stage II | The tumor is on, above, or below the vocal cords, but isn't affecting the normal movement of the vocal cords and the cancer has spread to another part of the larynx. |
| Stage III | The tumor has spread throughout the larynx, but hasn't spread further than the covering of the larynx and one or more vocal cords can't move. |
| Stage IV | The cancer has spread beyond the larynx to the thyroid gland, windpipe or esophagus, or to distant organs. |
A small organ of the lymphatic system containing many immune cells. Lymph nodes, also known as lymph glands, are the sites where many interactions between immune cells and foreign materials occur.
Signs and symptoms of throat cancer may include:
Mucus and possibly pus, bacteria and blood that is coughed up from the airways, typically as a result of an infection.
Your doctor will ask you questions about your medical history, any symptoms you have and possible risk factors. If your doctor has any concerns, you'll be referred to an ear, nose and throat specialist for further examination, investigation and management.
A barium swallow involves drinking a chalky substance that contains barium, followed by an X-ray or scan. This may be the first test performed if one of the symptoms is having trouble swallowing. The swallow can show a narrowing of the throat or a protrusion that are due to a mass in the throat.
A computerized tomography scan uses X-rays to develop a 3D image of the body. This type of scan can detect small cancers much more effectively. The scan may be used to identify the original site of the cancer and to establish the spread of the cancer within the head or neck area or to other more distant sites.
Magnetic resonance imaging is a 3D scan similar to CT, but uses magnetism instead of X-rays. An MRI scan is often performed when more detailed images of the cancer are required.
Positron emission tomography requires an injection with a radioactive label, or tracer. When combined with a CT scan, it produces images that can help assess the size, location and spread of a cancer.
During an upper endoscopy, you will be sedated and a slender telescopic tube will be inserted into your nose and throat. A tissue biopsy may be performed during this procedure if an abnormal lesion is found.
During a laryngoscopy, your voice box will be checked for abnormalities using a laryngoscope, a slender tube with an attached camera. The doctor will usually apply an anesthetic spray to numb your throat before the procedure.
A biopsy is a removal of a tissue sample for examination under a microscope. The biopsy is the only definite way of making a cancer diagnosis as it provides the most accurate analysis of the abnormal-looking cells.
The cancer and affected lymph nodes may be surgically removed. They are numerous different techniques for the surgical treatment of throat cancers, depending on the location, size and lymph nodes affected. Occasionally, reconstructive surgery may also be necessary to restore function and/or appearance, after the removal of the cancer. Your surgeon can help discuss surgical options with you. Surgery is often combined with adjuvant and/or neoadjuvant therapy for better outcomes.
Adjuvant therapy is given after surgery, with the aim of preventing the cancer from returning. It can take the form of radiotherapy and/or chemotherapy.
Like adjuvant therapy, neoadjuvant therapy also uses radiotherapy and/or chemotherapy, but is provided before surgery.
Chemotherapy works by attacking cancer cells and stopping their reproduction. Various medications are used, which are generally administered intravenously. They are often given in cycles, followed by rest periods, which help to reduce the toxic side effects of chemotherapy. Your doctor will monitor your dosage and treatment schedule to ensure optimal therapeutic dosage is administered, with minimum side effects.
Various medications are used in chemotherapy to treat cancer.
In this type of therapy, focused X-rays from an external beam radiation source are applied to the area where the cancer was located. Radiotherapy helps to reduce the recurrence of cancers at their original site. It can occasionally be used on its own for the treatment of very small cancers. Commonly, it is combined with surgery as adjuvant and/or neoadjuvant therapy.
Throat cancers are often treated by a group of health professionals including surgeons, oncologists (cancer specialists), radiation oncologists (radiation specialists), speech therapists, dieticians, psychologists and social workers. The team of health professionals help to prepare for treatment, coordinate therapies and assist in rehabilitation. They can be contacted for any assistance during the treatment process. They are likely to regularly review you in the years following your treatment to detect any cancer recurrence and assist you in your recovery.
Some people diagnosed with cancer seek out complementary and alternative therapies. None of these alternative therapies cure cancer, but some can help people feel better when used together with conventional medical treatment. It is important to discuss any treatments with your doctor before starting them.
Side effects associated with treatments include:
Advanced throat cancer can spread throughout the body via the bloodstream and lymphatic system (metastasize).
A network of vessels, lymph nodes, the spleen and other organs that transport lymph fluid between tissues and bloodstream.
The prognosis depends on the type and stage of cancer. For cancer of the laryngopharynx, the five-year survival rate is 65%, increasing to 72% for those who survive the first year and to 81% for those who survive five years. [1]
Your doctor, who specializes in cancer treatment (oncologist), will inform you of the prognosis.
In general, cancers associated with HPV infection tend to have better survival rates.
It is important to remember survival rates are only an indication, and are based upon the averages of previously treated patients. It is not an absolute prognosis for an individual. It is often difficult to accurately predict an individual's cure or survival rate. Constant advances in treatment are continually improving these statistics.
Cancer survival and prevalence in Australia: period estimates from 1982 to 2010. Australian Government – Australian Institute of Health and Welfare. Accessed 22 September 2014 from
There is no way to prevent throat cancer, but you can reduce your risk by not smoking, minimizing your alcohol consumption and eating a healthy diet high in fruit and vegetables.